is a synthetic psychedelic tryptamine with close structural similarities to the “magic mushroom” molecules psilocybin and psilocin. It was developed by the inventor of LSD Albert Hofmann, along with Franz Troxler, for Sandoz Ltd., the company that patented the drug in 1963 (incidentally the same year their LSD patents expired). Of the many “grey market” research chemicals out there, microdosing 4-AcO-DMT is probably among the safest. At macrodoses, its effects are comparable – although in some ways rather different – to those of psilocybin or psilocin. Most users report a full range of psychedelic visual effects, from color enhancement to vivid hallucinations, along with euphoria, ego loss, and mystical or religious experiences. And, as with psilocybin, microdoses have been linked to:
Increased empathy and sociability Introspection
Visual clarity and color enhancement
Motivation and energy
Relaxation, peace, and contentedness
Mental clarity and Focus
HOW DO YOU MICRODOSE 4-ACO-DMT?
Usually sold in powder form, 4-AcO-DMT can be taken orally or intranasally, among other methods. But for microdosing, oral administration seems to be the most obvious choice – if only for ease and simplicity. Be warned, though: it tastes pretty foul.
When measuring out doses, keep in mind that just a few milligrams more or less can lead to profoundly different effects. Going by anecdotal reports, effective microdoses range between 0.5 mg and 5 mg (although 5 mg may be too much for most people, producing a noticeable come-up, difficulties focusing, and scattered thoughts in general). 1 mg seems a reasonable microdose to start with, to be adjusted up or down as required on subsequent occasions. But since most affordable scales (such as the Gemini-20) are incapable of accurately weighing such tiny amounts, volumetric microdosing is probably your best bet.
It’s also worth noting that the precise concentration of your 4-AcO-DMT powder will depend on whether it’s in the form of a fumarate or hydrochloride (HCl) salt. Every 1.24 mg fumarate, for example, is expected to contain 1 mg 4-AcO-DMT, while the equivalent amount in HCl would be 1.15 mg for 1 mg 4-AcO-DMT.