4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class. It is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotonin receptorsin the brain.Buy 4-AcO-DMT in USA
The synthesis of 4-AcO-DMT was first reported in 1963 by Albert Hofmann and Franz Troxler. However, its properties were not examined and no further studies were carried out. A 1999 paper by David E. Nichols suggested it as a useful alternative to psilocybin for pharmacological research. Reports of human use began to surface following its appearance on the online research chemical market in the 2010s. Buy 4-AcO-DMT in USA
User reports indicate that the subjective effects of 4-AcO-DMT are near identical to those of psilocybin mushrooms.. Characteristic effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. 4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users. Particularly those seeking mystical-like or entheogenic experiences.
In the body O-acetylpsilocin is decelerated to psilocin by deacetylases/acetyltransferases during first pass metabolism and during subsequent passes through the liver (evident as psilacetin is also active via parenteral routes of ingestion).
Claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin differ: some users report that O-acetylpsilocin lasts slightly longer while others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin.
Some users find that the visual distortions produced by O-acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug. Despite this, there have been no controlled clinical studies to distinguish any effects of psilacetin, psilocin, and psilocybin from one another.